Conventional batch chemistry


The Center is equipped for traditional organic synthesis and for more demanding batch applications (such as experiments under strictly controlled atmosphere, high pressure and microwave applications). Remarquable routine equipment includes:

  • CEM Discovery SP with Active Vent for microwave activation at the research scale
  • Shimadzu Prominence-i HPLC (DAD, autosampler, 216 samples)
  • Shimadzu GC2014 (FID, autosampler, 12 samples)

Flow chemistry

The Center owns a remarquable set of continuous flow reactors for demanding applications including liquid-liquid, gas-liquid, photochemistry, high temperature/pressure applications and complex multistep sequences.

DSC_2352

● Corning Advanced-flow Lab Photo Reactor

Continuous flow reactor equipped for photochemical lab scale applications
Typical applications: lab scale process, R&D, optimization, lab-scale production for liq-liq, liq-gas, thermal or photochemical applications
Light source: high power LEDs (multiple wavelengths available)
Wetted-parts: metal free, glass, perfluorinated polymers, PEEK
Internal volume: 2.7 mL
Scale: 100+g/day
Operating conditions: -25 °C to 200 °C, up to 18 bar

Corning Advanced-flow Lab Photo Reactor_crop
[2] Corning Advanced-flow Low Flow Reactor_crop

● Corning Advanced-flow Low Flow Reactor

Continuous flow reactor for lab scale applications
Typical applications: lab scale process, R&D, optimization, lab-scale production for liq-liq, liq-gas, thermal applications
Wetted-parts: metal free, glass, perfluorinated polymers, PEEK
Internal volume: 0.5 mL (per fluidic module)
Scale: 100+g/day
Operating conditions: -25 °C to 200 °C, up to 18 bar

● Corning Advanced-flow G1 Reactor

Continuous flow reactor for pilot scale applications
Typical applications: pilot scale process, R&D, optimization for liq-liq, liq-gas, thermal applications
Wetted-parts: metal free, glass or SiC, perfluorinated polymers, PEEK
Internal volume: 8 mL (per fluidic module)
Scale: several kg/day
Operating conditions: -25 °C to 200 °C, up to 18 bar

[3] Corning Advanced-flow G1 Reactor_crop
[4] Phoenix Flow Reactor (ThalesNano)_crop

● Phoenix Flow Reactor (ThalesNano)

Continuous flow high temperature reactor compatible for homogeneous and heterogeneous liquid-liquid or gas liquid reactions.
Typical applications: lab scale process, R&D, optimization, lab-scale production for liq-liq, liq-gas, high temperature applications
Wetted-parts: SS
Internal volume: 0.9 to 18 mL
Scale: up to 100+g/day
Operating conditions: up to 450 °C, up to 100 bar

● H-Cube (ThalesNano)

Continuous flow high temperature/high pressure hydrogenation (deuteration) reactor compatible for homogeneous and heterogeneous reactions.
Typical applications: lab scale hydrogenation process, R&D, optimization
Wetted-parts: SS
Flow rate: 0.1 – 3 mL/min
Hydrogen generation: 25-30 mL/min
Water reservoir capacity: 100 mL
Scale: g/day
Operating conditions: up to 100 °C, up to 100 bar

[5] H-Cube (ThalesNano)
[6] CEM Discovery SP_format

● CEM Discovery SP

Microwave reactor equipped with flow cells for continuous flow applications
Typical applications: lab scale continuous flow MW optimization and production
Wetted-parts: glass, perfluorinated polymers, PEEK
Flow rate: 0.1 – 10 mL/min
Internal volume: up to 30 mL
Scale: 100+g/day
Operating conditions: up to 300 °C

● Flow IR (Mettler Toledo)

Device for in-line IR analysis equipped with a DTGS detector using HappGenzel apodization and a Silicon probe. High pressure flow heated cels of 10 or 50 µL are available

[7] Flow IR (Mettler Toledo)

Miscellaneous

Analytical support

Major analytical instrumentation (NMR, MS spectrometers, etc.) is provided by the Department of Chemistry and fellow laboratories:

● Center for Nuclear Magnetic Resonance (CREMAN)
● Laboratory of Mass Spectrometry
● Center for Education and Research on Macromolecules (CERM)

Computational support

Computational support for high-demanding calculations is provided by the University of Liège and the CéCI consortium of high-performance computing centers.

● SEGI – computational resources at the University of Liège
● CéCI – consortium of high-performance computing centers