Publications – CiTOS

Publications of 2024

“Innovative Chalcogenide Transfer Agent for Improved Aqueous Quantum Dot Synthesis”

G. Petit, C. Malherbe, P. Bianchi and J.-C. M. Monbaliu*

Chem. Sci. 2024, 15, 13115-13560

Featured in the “Celebrating the scientific accomplishments of RSC Fellows” themed collection

DOI: 10.1039/D4SC01135J

Front cover: September 2024

“The Catalytic Coupling of CO2 and Glycidol Toward Glycerol Carbonate”

C. Muzyka, D. V. Silva-Brenes, B. Grignard, C. Detrembleur and J.-C. M. Monbaliu*

ACS Catalysis. 2024, 14, 12454-12493

DOI: 10.1021/acscatal.4c01622

“Continuous Flow Synthesis and Crystallization of Modafinil: A Novel Approach for Integrated Manufacturing”

D. V. Silva-Brenes, S. Agrawal, V. López Mejías, J. Duconge, C. P. Vlaar, J.-C. M. Monbaliu* and Torsten Stelzer

React. Chem. Eng. 2024, Accepted

DOI: 10.1039/D4RE00273C

“New Opportunities for Organic Synthesis with Superheated Flow Chemistry”

P. Bianchi and J.-C. M. Monbaliu*

Acc. Chem. Res. 2024, 57, 2207-2218

DOI: 10.1021/acs.accounts.4c00340

Front cover: August 2024

“Glycerol and its derivatives as potential C-3 bio-based building blocks for accessing active pharmaceutical ingredients”

L. Bovy, R. Morodo, D. V. Silva-Brenes and J.-C. M. Monbaliu*

Green Chem. 2024, 26, 10029-10057

DOI: 10.1039/D4GC01957A

Front cover: September 2024

“Continuous flow synthesis of functional isocyanate-free poly(oxazolidone)s by step-growth polymerization”

F. Siragusa, L. Crane, P. Stiernet, T. Habets, B. Grignard, J.-C. M. Monbaliu* and C. Detrembleur*

ACS Macro Lett. 2024, 13, 644-650

DOI: 10.1021/acsmacrolett.4c00203

“On a seamlessly replicable circular photoreactor for lab-scale continuous flow applications”

Y.-H. Tsai, M. Cattoen, G. Masson, G. Christen, L. Traber, M. Donnard, F. Leroux, G. Bentzinger, S. Guizzetti and J.-C. M. Monbaliu*

React. Chem. Eng. 2024, 9, 1946-1655

DOI: 10.1039/D4RE00109E

Featured in the Special Edition celebrating Prof. K. F. Jensen’s 70th Birthday

Front cover: July 2024

“Preparation of Dinitrogen Trioxide for Organic Synthesis: A Phase Equilibrium Approach”

Y. Chen and J.-C. M. Monbaliu*

Chem. Eur. J. 2024, e202303516

DOI: 10.1002/chem.202303516

https://pubs.rsc.org/en/content/articlelanding/2023/GC/D3GC03470D

“A miniaturized ozonolysis flow platform for expeditious sulfur mustard warfare simulant neutralization”

M. Boddaert, P. Bianchi, D. V. Silva-Brenes, A. Musina, M. Winter, P. M. C. Roth, P.-Y. Renard, J. Legros and J.-C. M. Monbaliu*

Green Chem. 2024, 26, 1281-1288

DOI: 10.1039/D3GC03470D

Front cover: February 2024

Featured in the RSC Green Chemistry 25th anniversary themed collection

“Intensified continuous flow process for the scalable production of bio-based glycerol carbonate”

C. Muzyka, S. Renson, B. Grignard, C. Detrembleur, J.-C. M. Monbaliu*

Angew. Chem. Int. Ed. 2024, e202319060

DOI: 10.1002/anie.202319060

HOT Article 2024

“New insights into the role of VKORC1 polymorphisms for optimal warfarin dose selection in Caribbean Hispanic patients through an external validation of a population PK/P D model”

K. Rodríguez -Fernández, G. Reynaldo-Fernández, S. Reyes-González, C. de las Barreras, L. Rodríguez-Vera, C. Vlaar, J.-C. M. Monbaliu, T. Stelzer, J. Duconge, V. Mangas-Sanjuan

Biomed. Pharmacother. 2024, 170, 115977

DOI: 10.1016/j.biopha.2023.115977

Publications of 2023

“Intensified continuous flow process for the scalable production of bio-based glycerol carbonate”

C. Muzyka, S. Renson, B. Grignard, C. Detrembleur, and J.-C. M. Monbaliu*

ChemRxiv, 2023

DOI: 10.26434/chemrxiv-2023-wx40q

“Continuous flow intensification for the synthesis of high purity warfarin”

D. V. Silva-Brenes, S. K. Reyes-Vargas, J. Duconge, C. Vlaar, T. Stelzer, and J.-C. M. Monbaliu*

Org. Process. Res. Dev. 2024, 28, 1704-1712

DOI: 10.1021/acs.oprd.3c00338

“Revisiting the Paradigm of Reaction Optimization in Flow with a Priori Computational Reaction Intelligence”

P. Bianchi and J.-C. M. Monbaliu*

Angew. Chem. Int. Ed. 2023, 63, e202311526

DOI: 10.1002/anie.202311526

Open access – free to read

Part of the themed collection: Hot Topic : Flow Chemistry

Part of the themed collection: Hot Topic : Artificial Intelligence and Machine Learning

Monthly Highlights from the Literature: Some Items of Interest to Process R&D Chemists and Engineers

“Metal-free synthesis of estetrol key intermediate under intensified continuous flow conditions”

P. Bianchi, A. Dubart, M. Moors, D. Cornut, G. Duhirwe, J. Ampurdanés Vilanova, and J.-C. M. Monbaliu*

React. Chem. Eng. 2023, 8, 1565-1575

DOI: 10.1039/D3RE00051F

Front cover: June 2023

[2022][447x447] A perspective on automated advanced continuous flow manufacturing

“A perspective on automated advanced continuous flow manufacturing units for the upgrading of bio based chemicals towards pharmaceuticals”

G. Kaisin*, L. Bovy, Y. Joyard, N. Maindron, V. Tadino, J.-C. M. Monbaliu*

J. Flow Chem, 2023, 23, 1349-1357

DOI: 10.1007/s41981-022-00247-9

[2022][447x86] Continuous Flow Photooxidative Degradation of Azo

“Continuous Flow Photooxidative Degradation of Azo Dyes with Biomass-derived Carbon Dots”

C. Campalani, G. Petit, J.-C. M. Monbaliu*, M. Selva and A. Perosa*

ChemPhotoChem, 2023, 7, e202200234

DOI: 10.1002/cptc.202200234

“Will the next generation of chemical plants be in miniaturized flow reactors?”

J.-C. M. Monbaliu* and J. Legros*

Lab Chip, 2023, 23, 1349-1357

DOI: 10.1039/D2LC00796G

Collaborative Front cover: March 2023

Lab on a Chip HOT Articles 2022

Publications of 2022

“On Demand Flow Platform for the Generation of Anhydrous Dinitrogen Trioxide and Its Further Use in N-Nitrosative Reactions“

Y. Chen, S. Renson, J.-C. M. Monbaliu*

Angew. Chem. Int. Ed. 2022, 61, e202210146

DOI: 10.1002/anie.202210146

Open access – free to read

Part of the themed collection: Hot Topic : Flow Chemistry

“Accelerating the End-to-end Production of Cyclic Phosphate Monomers with Modular Flow Chemistry“

R. Morodo, R. Riva, N. M. S. van den Akker, D. G. Molin, C. Jerome and J.-C. M. Monbaliu*

Chemical Science, 2022, 10699-10706

DOI: 10.1039/D2SC02891C

Open access – free to read

2022 Chemical Science Hot Articles

2022 ChemSci Pick of the Week

“Development and validation of an integrated microfluidic device with an in-line Surface Enhanced Raman Spectroscopy (SERS) detection of glyphosate in drinking water“

G. Emonds-Alt, C. Malherbe, A. Kasemiire, H. T. Avohou, P. Hubert, E. Ziemons, J.-C. M. Monbaliu, G. Eppe

Talanta, 2022, 249, 123640

DOI: 10.1016/j.talanta.2022.123640

[2022][447x219] A Continuous Flow Generator

“A Continuous Flow Generator of Organic Hypochlorites for the Neutralization of Chemical Warfare Agent Simulants”

V.-E. H. Kassin, D. V. Silva-Brenes, T. Bernard, J. Legros, J.-C M. Monbaliu*

Green Chem. 2022, 24, 3167-3179

DOI: 10.1039/D2GC00458E

2022 Green Chemistry Hot Articles

“Continuous flow organocatalyzed methoxycarbonylation of benzyl alcohol derivatives with dimethyl carbonate”

T. Toupy, L. Bovy, J.-C M. Monbaliu*

J. Flow Chem. 2022, 2022, 12, 207–217

DOI: 10.1007/s41981-022-00216-2

“Out-smarting smart drug modafinil through flow chemistry”

D. V. Silva-Brenes, N. Emmanuel, V. Lopez-Mejias, J. Duconge Soler, C. Vlaar, T. Stelzer, J.-C M. Monbaliu*

Green Chem. 2022, 24, 2094–2103

DOI: 10.1039/D1GC04666G

2022 Green Chemistry Hot Articles

“Intensified Continuous Flow Michaelis–Arbuzov Rearrangement toward Alkyl Phosphonates”

T. Toupy, J.-C M. Monbaliu*

Org. Process Res. Dev. 2022, 26, 467–478

DOI: 10.1021/acs.oprd.1c00472

“Perspectives for the Upgrading of Bio-based Vicinal Diols within the Developing European Bioeconomy”

C. Muzyka, J.-C M. Monbaliu*

ChemSusChem, 2022, 15, e202102391

DOI: 10.1002/cssc.202102391

Cover feature: May 2022

“A multifaceted approach towards understanding the peculiar behavior of (?)-hydroxyiminophosphonates”

T. Toupy, C. Kune, K. Van Hecke, L. Quinton,* J.-C M. Monbaliu*

Org. Chem. Front., 2022, 9, 173-182

DOI: 10.1039/D1QO01564H

[2021][447x224]graphical_abstract-nitroso-pauline

“Three decades of unveiling the complex chemistry of C-nitroso species with computational chemistry”

P. Bianchi, J.-C. M. Monbaliu

Org. Chem. Front., 2022, 9, 223-264

DOI: 10.1039/D1QO01415C

Front cover: January 2022 issue 1

Publications of 2021

“Identification of the degradation products from alpha-ionone used as stabiliser in “green” propellants through its lifetime”

C. Damseaux,* G. Scholl, R. Dobson, A. Dejeaifve, X. Ma, I. E. Marko, C. Damblon, J.-C. M. Monbaliu, E. De Pauw, G. Eppe

Propellants Explos. Pyrotech. 2021, 46, 1653-1661

DOI: 10.1002/prep.202100191

[2021][447x359] Flow neutralization of sulfur-containing

“Flow neutralization of sulfur-containing chemical warfare agents with Oxone: packed-bed vs. aqueous solution”

A. Delaune, S. Mansour, B. Picard, P. Carrasqueira, I. Chataigner, L. Jean, P.-Y. Renard, J.-C. M. Monbaliu and Julien Legros*

Green Chem. 2021, 23, 2925-2930

DOI: 10.1039/D1GC00449B

“A Modular, Low Footprint and Scalable Flow Platform for the Expedient alpha-Aminohydroxylation of Enolizable Ketones”

V.-E. Kassin, R. Morodo, T. Toupy, I. Jacquemin, K. Van Hecke, R. Robiette and J.-C. M. Monbaliu*

Green Chem. 2021, 23, 2336-2351

DOI: 10.1039/D0GC04395H

Inside Front cover: March 2021 issue 21

Highlighted in: OPRD (Some items of Interest to Process R&D Chemists and Engineers)

Publications of 2020

“Au Nanobipyramids@mSiO2 Core-Shell Nanoparticles for Plasmon-Enhanced Singlet Oxygen Photooxygenations in Segmented Flow Microreactors”

C. Mendoza, A. Désert, D. Chateau, C. Monnereau, L. Khrouz, F. Lerouge, C. Andraud, J.-C. M. Monbaliu, S. Parola and B. Heinrichs

Nanoscale Adv. 2020, 2, 5280-5287

DOI: 10.1039/D0NA00533A

[2020][447x447] Continuous Flow Upgrading

“Continuous Flow Upgrading of Selected C2-C6 Platform Chemicals Derived from Biomass”

R. Gérardy, D. P. Debecker, J. Estager, P. Luis and J.-C. M. Monbaliu*

Chem. Rev. 2020, 120, 15, 7219-7347

DOI: 10.1021/acs.chemrev.9b00846

[2020][447x451] Continuous Flow Organophosphorus

“Continuous flow organophosphorus chemistry”

R. Morodo, P. Bianchi and J.-C. M. Monbaliu*

Eur. J. Org. Chem. 2020, 33, 5236-5277

DOI: 10.1002/ejoc.202000430

Front cover : September 2020 issue 33

Tagged as Very Important Paper

Featured in the special Collection YourJOC Talents 2020

“A safe and compact flow platform for the neutralization of a mustard gas simulant with air and light”

N. Emmanuel, P. Bianchi, J. Legros and J.-C. M. Monbaliu*

Green Chem. 2020, 22, 4105-4115

DOI: 10.1039/D0GC01142H

Outside back cover: July 2020 issue 13

“Scalable and robust photochemical flow process towards small spherical gold nanoparticles”

P. Bianchi, G. Petit and J.-C. M. Monbaliu*

React. Chem. Eng. 2020, 5, 1224-1236

DOI: 10.1039/D0RE00092B

Inside back cover: July 2020 issue 7

“The deoxydehydration (DODH) reaction: a versatile technology for accessing olefins from bio-based polyols”

N. Ntumba Tshibalonza and J.-C. M. Monbaliu*

Green Chem. 2020, 22, 4801-4848

DOI: 10.1039/D0GC00689K

Outside front cover: August 2020 issue 15

“Separation of bio-based chemicals using pervaporation”

W. Li, J. Estager, J.-C. M. Monbaliu, D. Debecker and P. Luis

J. Chem. Technol. Biotechnol. 2020, 95, 2311–2334

DOI: 10.1002/jctb.6434

[2020] Radical C-H F-Difluoromethylation of [447x285]

“Radiosynthesis of [18F]difluoromethyl heteroaryl-sulfones for radical C-H 18F-difluoromethylation of heteroarenes by visible light photoredox catalysis”

A Lemos, L. Trump, B. Lallemand, P. Pasau, J. Mercier, C. Lemaire, J.-C. M. Monbaliu, C. Genicot and A. Luxen

Catalysts 2020, 10, 275

DOI: 10.3390/catal10030275

[2019] Metal-free hydroxylation [447x168]

“Metal-free hydroxylation of tertiary ketones under intensified and scalable continuous flow conditions”

V.-E. H. Kassin, T. Toupy, G. Petit, P. Bianchi, E. Salvadeo and J.-C. M. Monbaliu*

J. Flow Chem. 2020, 10, 167-179

DOI: 10.1007/S41981-019-00073-6

[2020] Supported ionic liquid membranes for the separation [447x310]

“Supported ionic liquid membranes for the separation of methanol/dimethyl carbonate mixtures by pervaporation”

W. Li, C. Molina Fernandez, J. Estager, J.-C. M. Monbaliu, D. Debecker and P. Luis

J. Membr. Sci. 2020, 598, 117790

DOI: 10.1016/j.memsci.2019.+117790

“Development of a sustainable continuous flow approach toward allantoin”

E. Salvadeo and J.-C. M. Monbaliu

J. Flow Chem. 2020, 10, 251-257

DOI: 10.1007/S41981-019-00056-7

Publications of 2019

[2019] Versatile and scalable synthesis of cyclic organic carbonates [447x193]

“Versatile and scalable synthesis of cyclic organic carbonates under organocatalytic continuous flow conditions”

R. Gérardy, J. Estager, P. Luis, D. P. Debecker and J.-C. M. Monbaliu*

Catal. Sci. Technol. 2019, 9, 6841-6851

DOI: 10.1039/C9CY01659G

Outside Front Cover: December 2019 issue 24

[2019] Understanding chemical interaction [447x223]

“Understanding chemical interaction between phosphonate-derivative molecules and silver surface cluster in SERS: a combined experimental and computational approach”

G. Emonds-Alt, B. Mignolet, C. Malherbe, J.-C. M. Monbaliu, F. Remacle and G. Eppe*

Phys. Chem. Chem. Phys. 2019, 21, 22180-22187

DOI: 10.1039/C9CP01615E

[2019] Continuous flow upgrading of glycerol toward [447x122]

“Continuous flow upgrading of glycerol toward oxiranes and active pharmaceutical ingredients thereof”

R. Morodo, R. Gérardy, G. Petit and J.-C. M. Monbaliu*

Green Chem. 2019, 21, 4422-4433

DOI: 10.1039/C9GC01819K

“Expedient Preparation of Active Pharmaceutical Ingredient Ketamine under Sustainable Continuous Flow Conditions”

V.-E. Kassin, R. Gérardy, T. Toupy, D. Collin, E. Salvadeo, F. Toussaint, K. Van Hecke and J.-C. M. Monbaliu*

Green Chem. 2019, 21, 2952-2966

DOI: 10.1039/C9GC00336C

Part of the themed collection: 2019 Green Chemistry Hot Articles

Inside Front Cover: June 2019 issue 11

[2019] Native chemical ligation and extended methodologies

“Native chemical ligation and extended methodologies. Mecanisms, catalysis, scope and limitations”

V. Agouridas, O. El Mahdi, V. Diemer, M. Cargoët, J.-C. M. Monbaliu* and O. Melnyk*

Chem. Rev. 2019, 112, 7328-7443

DOI: 10.1021/acs.chemrev.8b00712

[2019] Solubility Determination and Correlation of Warfarin [447x234]

“Solubility Determination and Correlation of Warfarin Sodium 2-Propanol Solvate in Pure, Binary, and Ternary Solvent Mixture”

M. V. George De la Rosa, R. Santiago, J. Malavé Romero, J. Duconge, J.-C. M. Monbaliu, V. López-Mejías, T. Stelzer

J. Chem. Eng. Data 2019, 64, 1399–1413

DOI: 10.1021/acs.jced.8b00977

[2019] Finding the perfect match [447x150]

“Finding the perfect match: a combined computational and experimental study towards efficient and scalable photosensitized [2+2]cycloadditions in flow”

J. Williams, M. Nakano, R. Gérardy, J. A. Rincon, O. de Frutos, C. Mateos, J.-C. M. Monbaliu and C. O. Kappe

Org. Process Res. Dev. 2019, 23, 78-87

DOI: 10.1021/acs.oprd.8b00375

[2018] Solvent-free organocatalytic [447x269]

“Solvent-free organocatalytic preparation of cyclic organic carbonates under scalable continuous flow conditions”

Z. Wang, R. Gérardy, G. Gauron, C. Damblon and J.-C. M. Monbaliu*

React. Chem. Eng. 2019, 4, 17-26

DOI: 10.1039/c8re00209f

[2018] sustaining the transition[447x269]

“Sustaining the transition from petro- to biobased chemical industry with flow chemistry”

R. Gérardy, R. Morodo, J. Estager, P. Luis, D. P. Debecker, and J.-C. M. Monbaliu*

Top. Curr. Chem. 2019, 377:1

DOI: 10.1007/s41061-018-0222-3

Publications of 2018

[2018] Production of 3-butene-1,2-diol and vinyl ethylene carbonate from erythritol [447x269]

“A versatile biobased continuous flow strategy for the production of 3-butene-1,2-diol and vinyl ethylene carbonate from erythritol”

N. Ntumba Tshibalonza, R.Gérardy, Z. Alsafra, G. Eppe and J.-C. M. Monbaliu*

Green Chem. 2018, 20, 5147-5157

DOI: 10.1039/C8GC02468E

Part of the themed collection: 2018 Green Chemistry Hot Articles

[2018] Improving Continuous Flow Singlet [447x269]

“Improving Continuous Flow Singlet Oxygen Photooxygenations with Functionalized Mesoporous Silica Nanoparticles”

C. Mendoza, N. Emmanuel, C. A. Páez, L. Dreesen*, J.-C. M. Monbaliu* and B. Heinrich*

ChemPhotoChem 2018, 2, 890-897

DOI: 10.1002/cptc.201800148

Part of the special issue: Flow photochemistry

[2018] Application of pervaporation [447x269]

“Application of pervaporation in the bio-production of glycerol carbonate”

W. Li, R. Sreerangappa, J. Estager, J.-C. M. Monbaliu, D. P. Debecker, P. Luis

Chem. Eng. Process. 2018, 132, 127-136

DOI: 10.1016/j.cep.2018.08.014

[2018] Sorption and pervaporation study [447x269]

“Sorption and pervaporation study of methanol/diméthyl carbonate mixture with poly(etheretherketone) (PEEK-WC) membrane”

W. Li,F. Galiano, J. Estager, J.-C. M. Monbaliu, D. P. Debecker, A. Figoli, P. Luis

J. Memb. Sci. 2018, 567, 303-310

DOI: 10.1016/j.memsci.2018.09.040

[2018] Accelerated microfluidic [447x269]

“Accelerated microfluidic native chemical ligation at difficult amino acids toward cyclic peptides”

N. Ollivier, T. Toupy, R. C. Hartkoorn, R. Desmet, J.-C. M. Monbaliu* and O. Melnyk*

Nat. Commun. 2018, 9, 2847

DOI: 10.1038/s41467-018-05264-8

Highlighted in: SYNFACTS of the month

Featured in: 2018 Synthetic and Medicinal Chemistry issue of Nature Communication

“Continuous Flow Organic Chemistry: Successes and Pitfalls at the Interface with Current Societal Challenges”

R. Gérardy, N. Emmanuel, T. Toupy, V. Kassin, N. Ntumba Tshibalonza, M. Schmitz, J.-C. M. Monbaliu*

Eur. J. Org. Chem. 2018, 2301-2351

DOI:10.1002/ejoc.201800149

Tagged as Very Important Paper

Most Accessed paper in June 2018

Featured in the special Collection EurJOC Readers’ Choice 2019

“NOTA–PRGD2 and NODAGA–PRGD2: Bioconjugation, Characterization, Radiolabelling & Design Space”

M. Salvé, H. T. Avohou, J.-C. M. Monbaliu, P. Lebrun, C. Lemaire, C. Damblon, P. de Tullio, R. Hustinx and A. Luxen

J. Label. Cmpd. Radiopharm. 2018, 61, 487-500

DOI:10.1002/jlcr.3613

“Transitioning from macroscopic batch to microfluidic processes for the efficient singlet oxygen photooxygenation of methionine”

C. Mendoza, N. Emmanuel, C. Paez, L. Dreesen^*, J.-C. M. Monbaliu^* and B. Heinrichs^*

J. Photochem. Photobiol. 2018, 356,193-200

DOI:10.1016/j.jphotochem.2017.12.028)

Publications of 2017

“Continuous-flow preparation of g-butyrolactone scaffolds from renewable fumaric and itaconic acids under photosensitized conditions”

R. Gérardy, M. Winter, C. R. Horn., A. Vizza, K. Van Hecke and J.-C. M. Monbaliu^*

Org. Process Res. Dev. 2017, 21, 2012–2017

DOI:10.1021/acs.oprd.7b00314

“Scalable Photocatalytic Oxidation of Methionine under Continuous-Flow Conditions”

N. Emmanuel, C. Mendoza, M. Winter, C. Horn, A. Vizza, L. Dreesen, B. Heinrichs and J.-C. M. Monbaliu^*

Org. Process Res. Dev. 2017, 21, 1435-1438

DOI:10.1021/acs.oprd.7b00212

“Revisiting the deoxydehydration of glycerol towards allyl alcohol under continuous-flow conditions”

N. Ntumba Tshibalonza and J.-C. M. Monbaliu^*

Green Chem. 2017, 19, 3006-3013

DOI:10.1039/C7GC00657H

“Exploring the Fundamentals of Microreactor Technology with Multidisciplinary Lab Experiments Combining the Synthesis and the Characterization of Inorganic Nanoparticles”

N. Emmanuel, G. Emonds-Alt, M. Lismont^*, G. Eppe^* and J.-C. M. Monbaliu^*

J. Chem. Edu. 2017, 94, 775–780

DOI:10.1021/acs.jchemed.6b00899

“Assessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride”

R. Gérardy, M. Winter, A. Vizza and J.-C. M. Monbaliu^*

React. Chem. Eng. 2017, 2, 149-158

DOI:10.1039/C6RE00184J

Featured in: the themed collection Reaction Chemistry & Engineering Emerging Investigators

2016

“Expanding chemistry’s horizon with continuous-flow reactors” J.-C. M. Monbaliu^*, N. Emmanuel and R. Gérardy, Chimie Nouvelle 2016, 122, 18-26 (here)

“Compact and integrated approach for advanced end-to-end production, purification, and aqueous formulation of lidocaine hydrochloride”, J.-C. M. Monbaliu, T. Stelzer, E. Revalor, N. Weeranoppanant, K. F. Jensen, A. S. Myerson, Org. Process Res. Dev. 2016, 20, 1347-1353 (doi: 10.1021/acs.oprd.6b00165)

“On-demand continuous flow production of pharmaceuticals in a compact, reconfigurable system”, A. Adamo, R. L. Beingessner, M. Behnam, J. Chen, T. F. Jamison, K. F. Jensen, J.-C. M. Monbaliu, A. S. Myerson, E. Revalor, D. R. Snead, T. Stelzer, N. Weeranoppanant, S. Y. Wong, P. Zhang, Science 2016, 352, 61-67 (doi: 10.1126/science.aaf1337)
Highlighted on STAT, Technobahn, Science News, IEEE, MIT News, Scientific American, HNGN, MedicalXPress, Technology Review, Chemical & Engineering News

“Continuous-flow N-heterocyclic carbenes generation and organocatalysis”, L. Di Marco, M. Hans, L. Delaude and J.-C. M. Monbaliu^*, Chem. Eur. J. 2016, 22, 4508–4514 (doi: 10.1002/chem.201505135)
Tagged as hot paper and highlighted on Chemistry Views (here)

“Accelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates”, L. Raibaut, M. Cargoët, N. Ollivier, Y.-M. Chang, H. Drobecq, E. Boll, R. Desmet, J.-C. M. Monbaliu^* and Oleg Melnyk^*, Chem. Sci. 2016, 7, 2657-2665 (doi: 10.1039/C5SC03459K)

2015

“Continuous-flow thermolysis for the preparation of vinylglycine derivatives”, N. Lamborelle, J. Simon, A. Luxen and J.-C. M. Monbaliu^*, Org. Biomol. Chem. 2015, 13, 11602-11606 (doi: 10.1039/C5OB02036K)

“Preparation, reactivity and synthetic utility of simple benzotriazole derivatives”, R. Gérardy and J.-C. M. Monbaliu^*, Top. Heterocycl. Chem. 2015, 1-66 (doi: 110.1007/7081_2015_179)

“Efficient continuous flow benzotriazole activation and coupling of amino acids”, S. Seghers, F. E. A. Van Waes, A. Cukalovic, J.-C. M. Monbaliu et al., J. Flow Chem., 2015, 5, 220-227 (doi: 10.1556/1846.2015.00029)

2014

“New benzotriazole-based reagents for the phosphonylation of various N-, O- and S-nucleophiles”, Pandmand, A. D. Tiwari, S. Panda, J.-C. M. Monbaliu et al., Tetrahedron Lett. 2014, 55, 5898-5901 (doi: 10.1016/j.tetlet.2014.07.057)

“L’intensification des procédés chimiques, une approche radicale”, C. Henneuse, J.-C. M. Monbaliu, Athena 2014, 18-21 (here)

“Feruloyl benzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study towards O-, N-, S- and C-nucleophiles”, B. I. Roman, J.-C. M. Monbaliu et al., Eur. J. Org. Chem. 2014, 2594-2611. (doi: 10.1002/ejoc.201301895)

2013

“Capture of benzotriazole-based Mannich electrophiles by CH-acidic compounds”, J.-C. M. Monbaliu, L. K. Beagle et al., RSC Advances 2013, 3, 4152-4155 (doi: 10.1039/C3RA22826F)

“Governing parameters of long-range intramolecular S-to-N acyl transfers within chemical ligation of peptides”, J.-C. M. Monbaliu, G. Dive et al., J. Chem. Theory Comp. 2013, 927-934 (doi: 10.1021/ct300830k)

“Development, optimization and scale-up of biodiesel production from crude palm oil and effective use in developing countries”, A. Cukalovic, J.-C. M. Monbaliu et al., Biomass & Bioenerg. 2013, 56, 62-69 (doi: 10.1016/j.biombioe.2013.04.015)

2012

“Recent trends in Cys- and Ser/Thr-based chemical ligations for the elaboration of peptide constructs”, J.-C. M. Monbaliu and A. R. Katritzky, Chem. Commun. 2012, 48, 11601-11622 (doi: 10.1039/C2CC34434C)

“A convenient synthesis of difficult medium-sized cyclic peptides by Staudinger-mediated ring closure”, K. Ha, J.-C. M. Monbaliu et al., Org. Biomol. Chem. 2012, 10, 8055-8058 (doi: 10.1039/C2OB25996F)

“En route towards ?-benzotriazoyl nitroso derivatives”, J.-C. M. Monbaliu, Lucas Beagle et al., RSC Advances 2012, 2, 8941-8945 (doi: 10.1039/C2RA21311G)

“Efficient synthesis of 2,5-diketopiperazines by Staudinger-mediated cyclization”, L. Beagle, F. Hansen, J.-C. M. Monbaliu et al., Synlett 2012, 23, 2337-2340 (doi: 10.1055/s-0031-1290446)

“User-friendly and flexible Kiliani-Fisher reaction on ketoses using microreaction technology”, J.-C. M. Monbaliu, A. Cukalovic et al., J. Flow Chem. 2012, 2, 43-46 (doi: 10.1556/JFC-D-12-00003)

“Long-range intramolecular S-N acyl migration: a study of the formation of native peptide analogs via 13-, 15- and 16-membered cyclic transition states”, K. Ha, M. Chahar, J.-C. M. Monbaliu et al., J. Org. Chem. 2012, 77, 2637-2648 (doi: 10.1021/jo2023125)

“A new benzotriazole-mediated stereoflexible gateway to hetero-2,5-diketopiperazines”, J.-C. M. Monbaliu, F. K. Hansen et al., Chem. Eur. J. 2012, 18, 2632-2638 (doi: 10.1002/chem.201103143)

2011

“Continuous-flow production of alkyl nitrites”, J.-C. M. Monbaliu^*, J. Jorda et al., Chemistry Today 2011, 29, 80-82 (here)

“Electron-deficient 1- and 2-aza-1,3-dienes: a comprehensive survey of their synthesis and reactivity
J.-C. M. Monbaliu, K. G. R. Masschelein and C. V. Stevens, Chem. Soc. Rev. 2011, 40, 4708-4739 (doi: 10.1039/C1CS15070G)

“Effective production of the biodiesel additive STBE by a continuous flow process”, J.-C. M. Monbaliu, M. Winter et al., Bioresour. Technol. 2011, 102, 9304-9307 (doi: 10.1016/j.biortech.2011.07.007)

2010

“Straightforward hetero Diels-Alder cycloadditions of nitroso dienophiles by microreactor technology”,J.-C. M. Monbaliu, A. Cukalovic et al., Tetrahedron Lett. 2010, 51, 5830-5833 (doi: 10.1016/j.tetlet.2010.08.117)

“Feasibility study for industrial production of fuel additives from glycerol”,
J.-C. M. Monbaliu, M. Winter et al., Chemistry Today 2010, 28, 42-45 (here)

“[4+2] Cycloaddition of 1-phosphono-1,3-butadienes with nitroso-heterodienophiles: a new and versatile entry to polyfunctionalized ?– and ?-aminophosphonic derivatives”, J.-C. M. Monbaliu, B. Tinant et al, J. Org. Chem. 2010, 75, 5478-5486 (doi: 10.1021/jo100230r)

“HD-A cycloadditions of 1-diethoxyphosphoryl-1,3-butadiene with nitroso- and azo-heterodienophiles: a theoretical investigation”, J.-C. M. Monbaliu^*, G. Dive et al., J. Mol. Struct.: THEOCHEM. 2010, 959, 49-54 (doi: 10.1016/j.theochem.2010.08.004)

“Three unrelated sphingomyelin analogs spontaneously cluster into plasma membrane micrometric domains”, D. Tyteca, L. D’Auria, P. Van Der Smissen, T. Medts, S. Carpentier, J.-C. M. Monbaliu et al., BBA-Biomembrane 2010, 1978, 909-927 (doi: 10.1016/j.bbamem.2010.01.021)

“Novel chiral 1-phosphono-1,3-butadiene for asymmetric hetero Diels-Alder cycloadditions with nitroso and azodicarboxylate dienophiles”, J.-C. M. Monbaliu, D. Peeters et al., Tetrahedron Lett. 2010, 51, 1052-1055 (doi: 10.1016/j.tetlet.2009.12.063)

2009

“Is anthracene cofactor or spectator for the thermolysis of anthracenyl acylnitroso cycloadducts in the presence of a diene?”, J.-C. M. Monbaliu^*, J. Marchand-Brynaert et al., Tetrahedron Lett. 2009, 50, 2555-2558 (doi: 10.1016/j.tetlet.2009.03.062)

“A practical synthesis of 3-diethoxyphosphoryl-1,2-pyridazine derivatives”, J.-C. M. Monbaliu, J. Marchand-Brynaert, Synthesis 2009, 11, 1876-1880 (doi: 10.1055/s-0028-1088056)

(R)-4-phenyloxazolidin-2-thione: an efficient chiral auxiliary for [4+2] cycloaddition of 1-aminodienes and activated phosphonodienophiles, J.-C. M. Monbaliu, R. Robiette et al, Tetrahedron Lett. 2009, 50, 1314-1317 (doi: 10.1016/j.tetlet.2009.01.036)

2008

“Reactivity of (R)-4-phenyloxazolidin-2-thione chiral auxiliary: from deprotection to heterocyclic interconversion”, J.-C. M. Monbaliu, B. Tinant et al., Heterocycles 2008, 75, 2459-2475 (doi: 10.3987/COM-08-11410)

“[4+2] Cycloaddition of 1-phosphono-1,3-butadiene with azo- and nitroso-heterodienophiles”, J.-C. M. Monbaliu and J. Marchand-Brynaert, Tetrahedron Lett. 2008, 49, 1839-1842 (doi: 10.1016/j.tetlet.2008.01.050)

“NMR and X-ray diffraction analysis of 3-thioamido-5-phosphono-1-cyclohexene derivatives: Conformational and stereochemical assignments”, J.-C. M. Monbaliu, B. Tinant et al, J. Mol. Struct. 2008, 879, 113-118 (doi: 10.1016/j.molstruc.2007.08.018)